Management of Acute Promyelocytic Leukemia at Extremes of Age

Epigenetic effects of decitabine on acute lymphoblastic and acute promyelocytic leukemia cells

Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...

Treatment of acute promyelocytic leukemia.

Acute myeloid leukemia and acute promyelocytic leukemia.

The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...

Epidemiology of acute promyelocytic leukemia.

BACKGROUND The estimated incidence of acute promyelocytic leukemia (APL) is approximately 6 cases per 10 million people per year with no apparent differences between sexes. The age of APL cases is younger than that of other acute myeloid leukemias (AML). Spatial and temporal clusters of APL have been reported. These observations suggest a possible selective role for environmental and/or occupat...

Progress and criticalities in the management of acute promyelocytic leukemia

In only few decades, remarkable advances in biology and therapy have transformed acute promyelocytic leukemia (APL), once regarded as the most rapidly fatal human leukemia, into a paradigm of targeted treatment in human cancer, with most patients being nowadays curable without any or with only small amounts of conventional chemotherapy. Yet, the management of this rare subtype of leukemia remai...